It has become axiomatic that life naturally evolved out of nonliving materials billions of years ago. Given enough time and the chemical opportunity, living cells self-assemble.
However, the experts on the development of complex molecules from simpler ones, the synthetic chemists, do not know how this process actually occurs. There are no known pathways to create the components that make up a living cell from nonliving matter. They have no idea how amino acids (the building blocks of proteins and enzymes), nucleotides (the building blocks of DNA and RNA), saccharides (also called carbohydrates or sugars, the scaffolding for DNA and RNA, energy sources, and much more), and lipids (the main constituents of cell membranes) can be formed naturally on a prebiotic earth, especially before the formation of biological enzymes, to catalyze many of the requisite chemical reactions.